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KMID : 0369319940140010055
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Allergy
1994 Volume.14 No. 1 p.55 ~ p.64
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The Reliability of Saliva Theophyiline Concentrations as a Guide to Serum theophylline Concentrations
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오신근/Charles D.Sands
권순완/윤운기/류한선/손기호
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Abstract
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Theophylline is widely used in Korean Pediatric patients in the treatment of asthma and neonatal apnea. To achieve adequate bronchodilation and avoid side effects, It is generally accepted that the serum theophylline concentration should be
maintained
between 10 and 20mcg/ml. The measurement of this serum concentration usually requires a 3~5cc blood sample which on many occasions is repeated several times. In the pediatric population, especially, this exposes the children to multiple
venipuncture
with it´s potential associated trauma. To evaluate the reliability of salivary theophylline levels as a guide to serum theophylline levels, we studied the twenty of asthmatic children, who were admitted admitted to our hospital and received
intravenous
aminophylline and oral sustained release theophylline.
The mean theophylline concentration of Group I were 10.11±4.89mcg/ml in serum and 6.09±3.24mcg/ml in saliva. A strong correlation between the serum and saliva rtheophylline levels, r=0.87, was noted and it is statistically significant.
Regression
Equation was serum conc.=1.3050×saliva conc.+2.1624.
Also there was a good correlation between the predicted and actual theophylline concentrations, r=0.78, and no significant difference between two values in Group II. These suggest that the determination of salivary theophylline concentration may
be
a
convenient. Noninvasive method for routine monitoring of serum theophylline concentration.
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